Laser transit anemometer measurements on a slender cone in the Langley unitary plan wind tunnel

A laser transit anemometer (LTA) system was used to probe the boundary layer on a slender (5 degree half angle) cone model in the Langley unitary plan wind tunnel. The anemometer system utilized a pair of laser beams with a diameter of 40 micrometers spaced 1230 micrometers apart to measure the transit times of ensembles of seeding particles using a cross-correlation technique. From these measurements, boundary layer profiles around the model were constructed and compared with CFD calculations. The measured boundary layer profiles representing the boundary layer velocity normalized to the edge velocity as a function of height above the model surface were collected with the model at zero angle of attack for four different flow conditions, and were collected in a vertical plane that bisected the model's longitudinal center line at a location 635 mm from the tip of the forebody cone. The results indicate an excellent ability of the LTA system to make velocity measurements deep into the boundary layer. However, because of disturbances in the flow field caused by onboard seeding, premature transition occurred implying that upstream seeding is mandatory if model flow field integrity is to be maintained. A description and results of the flow field surveys are presented

Wildcat Bridge - I-65 Artesion Well/Geotechnical/Structural

In this session we will discuss the emergency design and repair of the I-65 bridge over Wildcat Creek in Tippecanoe County during the summer of 2015 that closed I-65 northbound

A Case Study of Error in Survey Reports of Move Month Using the U.S. Postal Service Change of Address Records

Correctly recalling where someone lived as of a particular date is critical to the accuracy of the once-a-decade U.S. decennial census. The data collection period for the 2010 Census occurred over the course of a few months: February to August, with some evaluation operations occurring up to 7 months after that. The assumption was that respondents could accurately remember moves and move dates on and around April 1st up to 11 months afterwards. We show how statistical analyses can be used to investigate the validity of this assumption by comparing self-reports and proxy-reports of the month of a move in a U.S. Census Bureau survey with an administrative records database from the U.S. Postal Service containing requests to forward mail filed in March and April of 2010. In our dataset, we observed that the length of time since the move affects memory error in reports of a move and the month of a move. Also affecting memory error of moves is whether the respondent is reporting for themselves or another person in the household . This case study is relevant to surveys as well as censuses because move dates and places of residence often serve as anchors to aid memory of other events in questionnaires

Wind Tunnel Seeding Systems for Laser Velocimeters

The principal motivating factor for convening the Workshop on the Development and Application of Wind Tunnel Seeding Systems for Laser Velocimeters is the necessity to achieve efficient operation and, most importantly, to insure accurate measurements with velocimeter techniques. The ultimate accuracy of particle scattering based laser velocimeter measurements of wind tunnel flow fields depends on the ability of the scattering particle to faithfully track the local flow field in which it is embedded. A complex relationship exists between the particle motion and the local flow field. This relationship is dependent on particle size, size distribution, shape, and density. To quantify the accuracy of the velocimeter measurements of the flow field, the researcher has to know the scattering particle characteristics. In order to obtain optimum velocimeter measurements, the researcher is striving to achieve control of the particle characteristics and to verify those characteristics at the measurement point. Additionally, the researcher is attempting to achieve maximum measurement efficiency through control of particle concentration and location in the flow field

ATP Binding Cassette Sub-family Member 2 (ABCG2) and Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation

Background: ATP binding cassette sub-family member 2 (ABCG2) is a welldefined efflux transporter found in a variety of tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work which compared data from the ToxCast screening program with that from in-house studies suggested an association exists between exposure to xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis. Methods: mESC were grown for up to 9 days. Pharmacological inhibitors were used to assess transporter function with and without xenobiotic exposure. Proliferation and differentiation were evaluated using RedDot1 and quantiative reverse transcriptase-polymerase chain reaction, respectively. ABCG2 activity was assessed using a Pheophorbide a-based fluorescent assay. Protein expression was measured by capillary-based immunoassay. Results: ABCG2 activity increased in differentiating mESC. Treatment with K0143, an inhibitor of ABCG2, had no effect on proliferation or differentiation. As expected, mitoxantrone and topotecan, two chemotherapeutics, displayed increased toxicity in the presence of K0143. Exposure to K0143 in combination with chemicals predicted by ToxCast to regulate ABCG2 expression did not alter xenobiotic-induced toxicity. Moreover, inhibition of ABCG2 did not shift the toxicity of either tert-Butyl hydroperoxide or paraquat, two oxidative stressors. Conclusion: As previously reported, ABCG2 serves a protective role in mESC. The role of ABCG2 in regulating redox status, however, was unclear. The hypothesis that ABCG2 plays a fundamental role during mESC differentiation or that regulation of the receptor by xenobiotics may be associated with altered mESC differentiation could not be supported

Using infectious intestinal disease surveillance data to explore illness aetiology; a cryptosporidiosis case study.

Infectious intestinal disease (IID) surveillance data are an under-utilised information source on illness geography. This paper uses a case study of cryptosporidiosis in England and Wales to demonstrate how these data can be converted into area-based rates and the factors underlying illness geography investigated. Ascertainment bias is common in surveillance datasets, and we develop techniques to investigate and control this. Rural areas, locations with many livestock and localities with poor water treatment had elevated levels of cryptosporidiosis. These findings accord with previous research validating the techniques developed. Their use in future studies investigating IID geography is therefore recommended

Ultrasmall Mixed Eu−Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have a long-term impact on the quality of life for survivors of all ages. However, there remains no approved treatment that improves outcomes following TBI, which is partially due to poor delivery of therapies into the brain. Therefore, there is a significant unmet need to develop more effective delivery strategies that increase the accumulation and retention of potentially efficacious treatments in the injured brain. Recent work has revealed that nanoparticles (NPs) may offer a promising approach for site-specific delivery; however, a detailed understanding of the specific NP properties that promote brain accumulation and retention are still being developed. Multimodal imaging plays a vital role in the understanding of physicochemical properties that initiate the uptake and accumulation of NPs in the brain at both high spatial (e.g., fluorescence imaging) and temporal (e.g., magnetic resonance imaging, MRI) frequency. However, many NP systems that are currently used in TBI only provide contrast in a single imaging modality limiting the imaging data that can be obtained, and those that offer multimodal imaging capabilities have complicated multistep synthesis methods. Therefore, the goal of this work was to develop an ultrasmall NP with simple fabrication capable of multimodal imaging. Here, we describe the development, characterization, accumulation, and retention of poly(ethylene glycol) (PEG)-coated europium−gadolinium (Eu−Gd) mixed magnetic NPs (MNPs) in a controlled cortical impact mouse model of TBI. We find that these NPs having an ultrasmall core size of 2 nm and a small hydrodynamic size of 13.5 nm can be detected in both fluorescence and MR imaging modalities and rapidly accumulate and are retained in injured brain parenchyma. These NPs should allow for further testing of NP physicochemical properties that promote accumulation and retention in TBI and other disease models

The influences of the Magellanic Clouds on the Galaxy: Pole shift, warp, and star formation history

We investigate how the Large Magellanic Cloud (LMC) influences the evolution of the Galaxy after the LMC enters into the virial radius of the dark matter halo of the Galaxy for the first time. Both the Galaxy and the LMC are modeled as N-body particles in our models so that the dynamical influences of the LMC on the Galaxy can be investigated in a fully self-consistent manner. Furthermore, the orbital parameters for the LMC are carefully chosen such that the present location of the LMC in the Galaxy can be rather precisely reproduced in our simulations. We particularly investigate the influences of the LMC on the precession rate, the outer stellar and gaseous structures, and the star formation history of the Galaxy. Our principals results are summarized as follows. The LMC-Galaxy dynamical interaction can cause "pole shift" (or irregular precession/nutation) of the Galaxy and the typical rate of pole shift (dot {\theta}_{d}) is ~2 degree Gyr^{-1} corresponding to ~ 7 muas yr^{-1}. The LMC-Galaxy interaction induces the formation of the outer warp structures of the Galaxy, which thus confirms the results of previous numerical simulations on the formation of the Galactic warp. The LMC-Galaxy interaction also induces the formation of outer (R>20 kpc) spiral arms and increases the vertical velocity dispersion of the outer disk significantly. The mean star formation rate of the Galaxy for the last several Gyrs can be hardly influenced by the LMC's tidal force. The age and metallicity distribution of stars in the solar-neighborhood (7 kpc < R < 10 kpc) for the last several Gyr can be only slightly changed by the past LMC-Galaxy interaction. Based on these results, we discuss how the possible ongoing Galactic pole shift with 10 muas yr^{-1} can be detected by future observational studies by GAIA.Comment: 19 pages, 25 figures, accepted for the publication of MNRA

Climate change and food security: health impacts in developed countries.

BACKGROUND: Anthropogenic climate change will affect global food production, with uncertain consequences for human health in developed countries. OBJECTIVES: We investigated the potential impact of climate change on food security (nutrition and food safety) and the implications for human health in developed countries. METHODS: Expert input and structured literature searches were conducted and synthesized to produce overall assessments of the likely impacts of climate change on global food production and recommendations for future research and policy changes. RESULTS: Increasing food prices may lower the nutritional quality of dietary intakes, exacerbate obesity, and amplify health inequalities. Altered conditions for food production may result in emerging pathogens, new crop and livestock species, and altered use of pesticides and veterinary medicines, and affect the main transfer mechanisms through which contaminants move from the environment into food. All these have implications for food safety and the nutritional content of food. Climate change mitigation may increase consumption of foods whose production reduces greenhouse gas emissions. Impacts may include reduced red meat consumption (with positive effects on saturated fat, but negative impacts on zinc and iron intake) and reduced winter fruit and vegetable consumption. Developed countries have complex structures in place that may be used to adapt to the food safety consequences of climate change, although their effectiveness will vary between countries, and the ability to respond to nutritional challenges is less certain. CONCLUSIONS: Climate change will have notable impacts upon nutrition and food safety in developed countries, but further research is necessary to accurately quantify these impacts. Uncertainty about future impacts, coupled with evidence that climate change may lead to more variable food quality, emphasizes the need to maintain and strengthen existing structures and policies to regulate food production, monitor food quality and safety, and respond to nutritional and safety issues that arise